Sexual stage development of cryptosporidia in the Caco-2 cell line-Reference-Cited by-同舟云学术

Sexual stage development of cryptosporidia in the Caco-2 cell line

Published:1991-12 Issue:12 Volume:59 Page:4610-4613
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Buraud M¹,Forget E¹,Favennec L¹,Bizet J¹,Gobert J G¹,Deluol A M¹

Affiliation:

1. Laboratoire de Biologie Animale et Parasitaire, Faculté des Sciences Pharmaceutiques et Biologiques, 4, Paris, France.

Abstract

We used the spontaneously differentiated human intestinal epithelial cell line Caco-2 to develop an in vitro model of Cryptosporidium sp. infection. The mean cell infection rate was 3% +/- 2%. Asexual stages of cryptosporidia were observed on day 2 postinoculation. Transmission electron microscopy showed the presence of macrogametes at day 5. This cell line appears to be suited to the study of the mechanisms by which biological agents inhibit both sexual and asexual development of cryptosporidia.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.59.12.4610-4613.1991

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