Assembly of SNAPc, Bdp1, and TBP on the U6 snRNA Gene Promoter in Drosophila melanogaster-Reference-Cited by-同舟云学术

Assembly of SNAPc, Bdp1, and TBP on the U6 snRNA Gene Promoter in Drosophila melanogaster

Published:2020-05-28 Issue:12 Volume:40 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Kim Mun Kyoung¹,Tranvo An¹,Hurlburt Ann Marie²,Verma Neha²,Phan Phuc¹,Luo Jie³,Ranish Jeff³,Stumph William E.¹

Affiliation:

1. Department of Chemistry and Biochemistry and Molecular Biology Institute, San Diego State University, San Diego, California, USA

2. Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, California, USA

3. Institute for Systems Biology, Seattle, Washington, USA

Abstract

U6 snRNA is transcribed by RNA polymerase III (Pol III) and has an external upstream promoter that consists of a TATA sequence recognized by the TBP subunit of the Pol III basal transcription factor IIIB and a proximal sequence element (PSE) recognized by the small nuclear RNA activating protein complex (SNAPc). Previously, we found that Drosophila melanogaster SNAPc (DmSNAPc) bound to the U6 PSE can recruit the Pol III general transcription factor Bdp1 to form a stable complex with the DNA.

Funder

California Metabolic Research Foundation

National Science Foundation

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00641-19

Reference47 articles.

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