Electrocardiographic Safety of Repeated Monthly Dihydroartemisinin-Piperaquine as a Candidate for Mass Drug Administration

Author:

Millat-Martínez Pere12,Ila Rhoda1,Laman Moses34,Robinson Leanne456,Karunajeewa Harin67,Abel Haina8,Pulai Kevin8,Sanz Sergi2910,Manning Laurens1112,Moore Brioni1113,Bassat Quique2141516ORCID,Mitjà Oriol2817ORCID

Affiliation:

1. Lihir Malaria Elimination Programme (LMEP), Lihir Island, New Ireland Province, Papua New Guinea

2. ISGlobal, Hospital Clínic Universitat de Barcelona, Barcelona, Spain

3. Department of Paediatrics, Modilon Hospital, Madang, Papua New Guinea

4. Papua New Guinea Institute of Medical Research (IMR), Madang, Papua New Guinea

5. Burnet Institute, Melbourne, Victoria, Australia

6. Division of Population Health and Immunity, Walter and Eliza Hall Institute, Parkville, Victoria, Australia

7. Western Centre for Health Research and Education, Western Health, Melbourne, Victoria, Australia

8. Lihir Medical Centre, International SOS-Newcrest Mining, Lihir Island, New Ireland Province, Papua New Guinea

9. Biostatistics Unit, Department of Public Health, Faculty of Medicine, University of Barcelona, Barcelona, Spain

10. CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain

11. Medical School, University of Western Australia, Harry Perkins Research Institute, Fiona Stanley Hospital, Murdoch, Western Australia, Australia

12. Department of Infectious Diseases, Fiona Stanley Hospital, Murdoch, Western Australia, Australia

13. School of Pharmacy and Biomedical Sciences, Curtin University, Perth, Western Australia, Australia

14. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain

15. Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique

16. Paediatric Infectious Diseases Unit, Paediatrics Department, Hospital Sant Joan de Déu (University of Barcelona), Barcelona, Spain

17. Division of Public Health, School of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea

Abstract

Mass drug administration (MDA) of sequential rounds of antimalarial drugs is being considered for use as a tool for malaria elimination. As an effective and long-acting antimalarial, dihydroartemisinin-piperaquine (DHA-PQP) appears to be suitable as a candidate for MDA.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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