Expansion of the Plaquing Host Range and Improvement of the Absorption Rate of a T5-like Salmonella Phage by Altering the Long Tail Fibers

Author:

Zhang Jing1ORCID,Ning Houqi1,Lin Hong1,She Jiaying1,Wang Luokai1,Jing Yujie1,Wang Jingxue1ORCID

Affiliation:

1. School of Food Science & Engineering, Ocean University of China, Qingdao, Shandong Province, China

Abstract

Genetic editing can be used to change or expand the host range of phages and have been successfully applied in T2, T4 and other phages to obtain engineered phages. However, there are hardly any similar reports on T5-like phages due to that the determinant regions related to their host ranges have not been completely clarified and the editing of T5-like phages is more difficult compared to other phages.

Funder

China Agriculture Research System

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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