Microscopic and Submicroscopic Asymptomatic Plasmodium falciparum Infections in Ghanaian Children and Protection against Febrile Malaria-Reference-Cited by-同舟云学术

Microscopic and Submicroscopic Asymptomatic Plasmodium falciparum Infections in Ghanaian Children and Protection against Febrile Malaria

Published:2020-09-18 Issue:10 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Adu Bright¹^ORCID,Issahaque Quratul-ain¹,Sarkodie-Addo Tracy¹,Kumordjie Selassie¹,Kyei-Baafour Eric¹,Sinclear Caleb K.¹,Eyia-Ampah Sophia¹,Owusu-Yeboa Eunice¹,Theisen Michael²³,Dodoo Daniel¹

Affiliation:

1. Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana

2. Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark

3. Centre for Medical Parasitology at Department of International Health, Immunology, and Microbiology and Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

Abstract

Naturally acquired immunity to Plasmodium falciparum malaria is thought to be nonsterile and sustained by persistence of low-level parasitemia. This study assessed the association between baseline microscopic and submicroscopic asymptomatic P. falciparum infections and antimalarial antibody levels and whether these parasitemia modify protective associations between antibody levels and malaria in Ghanaian children. Healthy children ( N = 973, aged 0.

Funder

Udenrigsministeriet

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00125-20

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