Chlamydia Deficient in Plasmid-Encoded pGP3 Is Prevented from Spreading to Large Intestine-Reference-Cited by-同舟云学术

Chlamydia Deficient in Plasmid-Encoded pGP3 Is Prevented from Spreading to Large Intestine

Published:2020-05-20 Issue:6 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Huo Zhi¹²,He Conghui¹³,Xu Ying¹²,Jia Tianjun³,Wang Jie²,Zhong Guangming¹

Affiliation:

1. Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

2. Department of Immunology, Xiangya School of Medicine, Central South University, Hunan, China

3. Department of Immunology, Medical College of Hebei North University, Hebei, China

Abstract

The cryptic plasmid pCM is critical for chlamydial colonization in the gastrointestinal tract. Nevertheless, orally inoculated plasmid-free Chlamydia sp. was still able to colonize the gut. Surprisingly, orally inoculated Chlamydia sp. deficient in only plasmid-encoded pGP3 was no longer able to colonize the gut. A comparison of live organism recoveries from individual gastrointestinal tissues revealed that pGP3-deficient Chlamydia sp. survived significantly better than plasmid-free Chlamydia sp.

Funder

US NIAID

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00120-20

Reference52 articles.

1. Longitudinal prevalence and faecal shedding of Chlamydia pecorum in sheep

2. Aberrant chlamydial developmental forms in the gastrointestinal tract of pigs spontaneously and experimentally infected with Chlamydia suis

3. In Vivo and Ex Vivo Imaging Reveals a Long-Lasting Chlamydial Infection in the Mouse Gastrointestinal Tract following Genital Tract Inoculation