Hypoxia-Inducible Factor Signaling in Macrophages Promotes Lymphangiogenesis in Leishmania major Infection-Reference-Cited by-同舟云学术

Hypoxia-Inducible Factor Signaling in Macrophages Promotes Lymphangiogenesis in Leishmania major Infection

Published:2021-07-15 Issue:8 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Bowlin Anne¹,Roys Hayden¹,Wanjala Humphrey¹,Bettadapura Manjunath¹,Venugopal Gopinath¹,Surma Jessica¹,Simon M. Celeste²,Weinkopff Tiffany¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

2. Abramson Family Cancer Research Institute, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

Vascular remodeling is a phenomenon seen in the cutaneous lesions formed during infection with Leishmania parasites. Within the lesion, Leishmania major infection leads to the infiltration of inflammatory cells, including macrophages, and is associated with hypoxic conditions and lymphangiogenesis in the local site.

Funder

George W. Donaghey Foundation

HHS | NIH | National Institute of General Medical Sciences

Oak Ridge Associated Universities

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00124-21

Reference48 articles.

1. Leishmaniasis Worldwide and Global Estimates of Its Incidence