Affiliation:
1. Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
2. Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
Abstract
ABSTRACT
Acute inflammatory reactions represent the major cause of irreversible neuropathy in leprosy. These tissue-destroying episodes have considerable overlap with acute immunological complications (flares) in several chronic (autoimmune) diseases that similarly warrant early detection. However, the lack of diagnostic tests impedes early diagnosis of these reactions. Here, we evaluated a user-friendly multiplex lateral flow assay for the simultaneous detection of IP-10 and anti-phenolic glycolipid I antibodies for longitudinally monitoring early onset and treatment of leprosy reactions.
Funder
Order of Malta Grants for Leprosy Research
The Heiser Program for Research in Leprosy and Tuberculosis of the New York Community Trust
The Q. M. Gastmann-Wichers Foundation
The Netherlands Leprosy Relief Foundation
European and Developing Countries Clinical Trials Partnership
Publisher
American Society for Microbiology
Subject
Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy
Cited by
23 articles.
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