Molecular Epidemiology of the SRL Pathogenicity Island-Reference-Cited by-同舟云学术

Molecular Epidemiology of the SRL Pathogenicity Island

Published:2003-02 Issue:2 Volume:47 Page:727-734
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Turner Sally A.¹,Luck Shelley N.¹,Sakellaris Harry¹,Rajakumar Kumar¹,Adler Ben¹

Affiliation:

1. Bacterial Pathogenesis Research Group, Department of Microbiology, Monash University, Victoria 3800, Australia

Abstract

ABSTRACT The Shigella resistance locus (SRL), which is carried on the SRL pathogenicity island (PAI) in Shigella flexneri 2a YSH6000, mediates resistance to the antibiotics streptomycin, ampicillin, chloramphenicol, and tetracycline. In the present study, we investigated the distribution and structural variation of the SRL and the SRL PAI in 71 Shigella isolates and 28 other enteric pathogens by PCR and Southern analysis. The SRL and SRL-related loci, although absent from the other enteric pathogens evaluated in this study, were found to be present in a number of Shigella isolates. SRL PAI markers were also present in the majority of strains carrying the SRL and SRL-related loci. PCR linkage studies with six of these strains demonstrated that the SRL is carried on elements similar in structure and organization to the YSH6000 SRL PAI, consistent with the hypothesis that the SRL PAI may be involved in the spread of multiple-antibiotic resistance in these strains.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.2.727-734.2003

Reference52 articles.

1. Al-Hasani, K., B. Adler, K. Rajakumar, and H. Sakellaris. 2001. Distribution and structural variation of the she pathogencity island in enteric bacterial pathogens. J. Med. Microbiol.50:780-786.

2. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

3. Ausubel F. A. R. Brent R. E. Kingston D. D. Moore J. G. Seidman J. A. Smith and K. Struhl. 1993. Current protocols in molecular biology. Greene Publishing and Wiley Interscience New York N.Y.

4. Complete Nucleotide Sequence of a 43-Kilobase Genomic Island Associated with the Multidrug Resistance Region of Salmonella enterica Serovar Typhimurium DT104 and Its Identification in Phage Type DT120 and Serovar Agona

5. Boyd, D. A., G. A. Peters, L.-K. Ng, and M. R. Mulvey. 2000. Partial characterization of a genomic island associated with the multidrug resistance region of Salmonella enterica Typhymurium DT104. FEMS Microbiol. Lett.189:285-291.

Cited by 30 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Genomic analysis of Shigella isolates from Lebanon reveals marked genetic diversity and antimicrobial resistance;Microbial Genomics;2023-12-15

2. Antimicrobial Resistance Dynamics in Chilean Shigella sonnei Strains Within Two Decades: Role of Shigella Resistance Locus Pathogenicity Island and Class 1 and Class 2 Integrons;Frontiers in Microbiology;2022-02-04

3. The evolutionary history of Shigella flexneri serotype 6 in Asia;Microbial Genomics;2021-12-14

4. Molecular Characterization of Multidrug-Resistant Yersinia enterocolitica From Foodborne Outbreaks in Sweden;Frontiers in Microbiology;2021-05-13

5. Global population structure and genotyping framework for genomic surveillance of the major dysentery pathogen, Shigella sonnei;Nature Communications;2021-05-11