Population Pharmacokinetics of Tenofovir in Pregnant and Postpartum Women Using Tenofovir Disoproxil Fumarate

Author:

Eke Ahizechukwu C.12ORCID,Shoji Kensuke3,Best Brookie M.45,Momper Jeremiah D.4,Stek Alice M.6,Cressey Tim R.78,Mirochnick Mark9,Capparelli Edmund V.45

Affiliation:

1. Division of Maternal Fetal Medicine, Department of Gynecology & Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

2. Doctoral Training Program (PhD), Graduate Training Program in Clinical Investigation (GTPCI), Johns Hopkins University School of Public Health, Baltimore, Maryland, USA

3. Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan

4. University of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, California, USA

5. Pediatrics Department, University of California San Diego–Rady Children’s Hospital San Diego, San Diego, California, USA

6. Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of Southern California School of Medicine, Los Angeles, California, USA

7. PHPT/IRD UMI 174, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

8. Department of Molecular & Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom

9. Division of Neonatology, Department of Pediatrics, Boston University School of Medicine, Boston, Massachusetts, USA

Abstract

Pharmacokinetics of drugs can be affected by physiologic changes during pregnancy. Our aim was to assess the influence of covariates on tenofovir (TFV) pharmacokinetics in pregnant and postpartum women receiving tenofovir disoproxil fumarate (TDF).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference33 articles.

1. Panel on Treatment of Pregnant Women with HIV Infection and Prevention of Perinatal Transmission. 2020. Recommendations for the use of antiretroviral drugs in pregnant women with HIV infection and interventions to reduce perinatal HIV transmission in the United States–August 26. https://clinicalinfo.hiv.gov/sites/default/files/guidelines/documents/PerinatalGL.pdf. Accessed 18 September 2020.

2. Gilead. 2004. TRUVADA (emtricitabine and tenofovir disoproxil fumarate) tablets for oral use—drug label. https://www.gilead.com/%7E/media/files/pdfs/medicines/hiv/truvada/truvada_pi.pdf. Accessed 16 September 2020.

3. Nucleotide Analogue Prodrug Tenofovir Disoproxil Enhances Lymphoid Cell Loading following Oral Administration in Monkeys

4. The simultaneous assay of tenofovir and emtricitabine in plasma using LC/MS/MS and isotopically labeled internal standards

5. Pharmacokinetics of tenofovir during pregnancy and postpartum

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