Pseudomonas aeruginosa MucD Regulates the Alginate Pathway through Activation of MucA Degradation via MucP Proteolytic Activity-Reference-Cited by-同舟云学术

Pseudomonas aeruginosa MucD Regulates the Alginate Pathway through Activation of MucA Degradation via MucP Proteolytic Activity

Published:2011-01 Issue:1 Volume:193 Page:286-291
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Damron F. Heath¹²,Yu Hongwei D.¹³²

Affiliation:

1. Departments of Biochemistry and Microbiology, Joan C. Edwards School of Medicine at Marshall University, Huntington, West Virginia 25755-9320

2. Progenesis Technologies, LLC, Bldg. 740, Rm. 4136, Dow Technology Park, 3200 Kanawha Turnpike, South Charleston, West Virginia 25303

3. Pediatrics, Joan C. Edwards School of Medicine at Marshall University, Huntington, West Virginia 25755-9320

Abstract

ABSTRACT Alginate overproduction in Pseudomonas aeruginosa can be caused by the proteolysis of the anti-sigma factor MucA regulated by the AlgW protease. Here, we show that inactivation of MucD, an HtrA/DegP homolog and alginate regulator, can bypass AlgW, leading to an atypical proteolysis of MucA that is dependent on the MucP protease.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.01132-10

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