Generation of human monoclonal antibodies that confer protection against pertussis toxin-Reference-Cited by-同舟云学术

Generation of human monoclonal antibodies that confer protection against pertussis toxin

Published:1992-03 Issue:3 Volume:60 Page:1258-1260
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Zaccolo M¹,Roggero S¹,Armellini D¹,Pegoraro L¹,Rappuoli R¹,Malavasi F¹

Affiliation:

1. Dipartimento di Genetica, Biologia e Chimica Medica, Università di Torino, Italy.

Abstract

A panel of human monoclonal antibodies reactive with pertussis toxin has been generated by means of Epstein-Barr virus infection. One of these, the 3F11 monoclonal antibody, showed the ability to neutralize in vitro and in vivo the toxic effects of the toxin. Western blot (immunoblot) analysis located the 3F11 epitope on the S3 subunit.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.60.3.1258-1260.1992

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