Affiliation:
1. Department of Developmental Therapeutics, The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77030
Abstract
Thienamycin, a new beta-lactam antibiotic, exhibited potent, broad-spectrum activity in vitro against gram-negative bacilli and gram-positive cocci, including many isolates resistant to currently available antibiotics. All isolates were inhibited at concentrations less than or equal to 25 μg/ml, with the exception of 12% of isolates of
Enterobacter
spp. and 3% of isolates of
Serratia marcescens
. Its activity decreased with an increase in inoculum concentration of from 10
5
to 10
7
cells per ml.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
52 articles.
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