Aztreonam plus Clavulanate, Tazobactam, or Avibactam for Treatment of Infections Caused by Metallo-β-Lactamase-Producing Gram-Negative Bacteria-Reference-Cited by-同舟云学术

Aztreonam plus Clavulanate, Tazobactam, or Avibactam for Treatment of Infections Caused by Metallo-β-Lactamase-Producing Gram-Negative Bacteria

Published:2019-05 Issue:5 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Emeraud Cécile¹²³⁴,Escaut Lelia⁵,Boucly Athénaïs⁴⁶⁷,Fortineau Nicolas¹²³,Bonnin Rémy A.²³⁴,Naas Thierry¹²³⁴^ORCID,Dortet Laurent¹²³⁴^ORCID

Affiliation:

1. Department of Bacteriology-Hygiene, Bicêtre Hospital, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, France

2. EA7361 “Structure, dynamic, function and expression of broad spectrum β-lactamases,” Paris-Sud University, Paris Saclay University, LabEx Lermit, Le Kremlin-Bicêtre, France

3. French National Reference Center for Antibiotic Resistance, Le Kremlin-Bicêtre, France

4. Paris-Sud University, Paris Saclay University, Faculty of Medicine, Le Kremlin-Bicêtre, France

5. Department of Infectious Diseases, Bicêtre Hospital, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, France

6. Department of Pneumology, Bicêtre Hospital, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, France

7. INSERM UMR_S 999, Marie Lannelongue Hospital, Le Plessis Robinson, France

Abstract

Metallo-β-lactamase (MBL)-producing Gram-negative bacteria are often extremely resistant, leading to a real therapeutic dead end. Here, we evaluated the in vitro and in vivo efficacy of aztreonam in combination with ceftazidime-avibactam, ceftolozane-tazobactam, or amoxicillin-clavulanate for the treatment of infections caused by MBL-producing Enterobacteriaceae , MBL-producing Pseudomonas aeruginosa , and extremely drug-resistant Stenotrophomonas maltophilia .

Funder

Agence Nationale de la Recherche

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00010-19

Reference21 articles.

1. Carbapenem resistance in Enterobacteriaceae: here is the storm!

2. Structural and Functional Aspects of Class A Carbapenemases

3. B1-Metallo-β-Lactamases: Where Do We Stand?