Posttranslational Regulation of Mycobacterium tuberculosis Extracytoplasmic-Function Sigma Factor σ L and Roles in Virulence and in Global Regulation of Gene Expression-Reference-Cited by-同舟云学术

Posttranslational Regulation of Mycobacterium tuberculosis Extracytoplasmic-Function Sigma Factor σ L and Roles in Virulence and in Global Regulation of Gene Expression

Published:2006-04 Issue:4 Volume:74 Page:2457-2461
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Dainese Elisa¹,Rodrigue Sébastien²,Delogu Giovanni³,Provvedi Roberta¹,Laflamme Liette²,Brzezinski Ryszard⁴,Fadda Giovanni³,Smith Issar⁵,Gaudreau Luc²,Palù Giorgio¹,Manganelli Riccardo¹

Affiliation:

1. Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy

2. Centre de Recherche sur les Mécanismes du Fonctionnement Cellulaire, Université de Sherbrooke, Sherbrooke, Québec, Canada

3. Institute of Microbiology, Catholic University of the Sacred Hearth, Rome, Italy

4. Centre de Valorisation de la Diversité Microbienne, Département de Biologie, Université de Sherbrooke, Sherbrooke, Québec, Canada;

5. TB Center, The Public Health Research Institute, Newark, New Jersey

Abstract

ABSTRACT In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL - rslA mutant strain was significantly attenuated in a mouse model of infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.74.4.2457-2461.2006

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