Adaptive Immunity-Dependent Intestinal Hypermotility Contributes to Host Defense against Giardia spp-Reference-Cited by-同舟云学术

Adaptive Immunity-Dependent Intestinal Hypermotility Contributes to Host Defense against Giardia spp

Published:2006-04 Issue:4 Volume:74 Page:2473-2476
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Andersen Yolanda S.¹,Gillin Frances D.²,Eckmann Lars¹

Affiliation:

1. Department of Medicine

2. Division of Infectious Diseases, Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093

Abstract

ABSTRACT Humans infected with Giardia exhibit intestinal hypermotility, but the underlying mechanisms and functional significance are uncertain. Here we show in murine models of giardiasis that small-intestinal hypermotility occurs in a delayed fashion relative to peak parasite burden, is dependent on adaptive immune defenses, and contributes to giardial clearance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.74.4.2473-2476.2006

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