Distinct Kinetics of Effector CD8 + Cytotoxic T Cells after Infection with Trypanosoma cruzi in Naïve or Vaccinated Mice-Reference-Cited by-同舟云学术

Distinct Kinetics of Effector CD8 + Cytotoxic T Cells after Infection with Trypanosoma cruzi in Naïve or Vaccinated Mice

Published:2006-04 Issue:4 Volume:74 Page:2477-2481
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Tzelepis Fanny¹,de Alencar Bruna C. G.¹,Penido Marcus L. O.²,Gazzinelli Ricardo T.²,Persechini Pedro M.³,Rodrigues Mauricio M.¹

Affiliation:

1. Centro Interdisciplinar de Terapia Gênica (CINTERGEN)

2. Departmento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo-Escola Paulista de Medicina, Rua Mirassol, 207, São Paulo-SP, Brazil, 04044-010

3. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais e Centro de Pesquisas René Rachou, FIOCRUZ, Avenida Augusto de Lima 1715, Barro Preto, 30190-002, Belo Horizonte, Minas Gerais, Brazil

Abstract

ABSTRACT The kinetics of effector CD8 + -T-cell responses to specific Trypanosoma cruzi epitopes was investigated after challenge. Our results suggest that the delayed kinetics differs from that observed in other microbial infections and facilitates the establishment of the disease in naïve mice. In contrast, in vaccinated mice, the swift CD8 + -T-cell response helps host survival after challenge.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.74.4.2477-2481.2006

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