Transcriptomic Signatures of Human Immunodeficiency Virus Post-Treatment Control

Author:

Wedrychowski Adam12,Martin Holly Anne12,Li Yijia3ORCID,Telwatte Sushama12,Kadiyala Gayatri Nikhila12,Melberg Meghan3,Etemad Behzad3,Connick Elizabeth4,Jacobson Jeffrey M.5,Margolis David M.67,Skiest Daniel8,Volberding Paul12,Hecht Frederick1,Deeks Steven1,Wong Joseph K.12,Li Jonathan Z.3,Yukl Steven A.12ORCID

Affiliation:

1. Department of Medicine, University of California, San Francisco, California, USA

2. Department of Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA

3. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

4. Department of Medicine, University of Arizona, Tucson, Arizona, USA

5. Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA

6. UNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

7. Departments of Medicine, Microbiology and Immunology, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

8. Department of Medicine, University of Massachusetts Medical School-Baystate, Springfield, Massachusetts, USA

Abstract

The findings presented here provide new insights into how HIV and cellular gene expression change after stopping ART in both noncontrollers and posttreatment controllers. Posttreatment control is associated with an early ability to limit increases in multiply-spliced HIV RNA, a delayed (and presumably immune-mediated) ability to reverse an initial rise in processive/completed HIV transcripts, and multiple differences in cellular gene expression pathways.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

AIDS Clinical Trials Group

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

California HIV/AIDS Research Program

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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