Evaluating the Breadth of Neutralizing Antibody Responses Elicited by Infectious Bursal Disease Virus Genogroup A1 Strains Using a Novel Chicken B-Cell Rescue System and Neutralization Assay

Author:

Reddy Vishwanatha R. A. P.1ORCID,Nazki Salik1,Brodrick Andrew J.2,Asfor Amin13,Urbaniec Joanna1,Morris Yasmin1,Broadbent Andrew J.12ORCID

Affiliation:

1. The Pirbright Institute, Woking, United Kingdom

2. Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA

3. Department of Pathology and Infectious Diseases, Faculty of Health and Medical Sciences, School of Veterinary Medicine, University of Surrey, Guilford, United Kingdom

Abstract

There is a need to evaluate the ability of vaccines to neutralize diverse IBDV genogroups and to better understand the relationship between HVR sequence, structure, and antigenicity. Here, we used a chicken B-cell line to rescue a panel of chimeric IBDVs with the HVR from seven diverse IBDV field strains and to conduct neutralization assays and protein modeling.

Funder

UKRI | Biotechnology and Biological Sciences Research Council

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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