The Global and Local Distribution of RNA Structure throughout the SARS-CoV-2 Genome-Reference-Cited by-同舟云学术

The Global and Local Distribution of RNA Structure throughout the SARS-CoV-2 Genome

Published:2021-02-10 Issue:5 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Tavares Rafael de Cesaris Araujo¹,Mahadeshwar Gandhar²,Wan Han³,Huston Nicholas C.²,Pyle Anna Marie¹³⁴^ORCID

Affiliation:

1. Department of Chemistry, Yale University, New Haven, Connecticut, USA

2. Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA

3. Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA

4. Howard Hughes Medical Institute, Chevy Chase, Maryland, USA

Abstract

The RNA genome of SARS-CoV-2 is among the largest and most complex viral genomes, yet its RNA structural features remain relatively unexplored. Since RNA elements guide function in most RNA viruses, and they represent potential drug targets, it is essential to chart the architectural features of SARS-CoV-2 and pinpoint regions that merit focused study.

Funder

China Scholarship Council-Yale World Scholars Program in Biomedical Sciences

HHS | National Institutes of Health

Howard Hughes Medical Institute

Yale University

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02190-20

Reference70 articles.