ICP22 of Herpes Simplex Virus 1 Decreases RNA Polymerase Processivity-Reference-Cited by-同舟云学术

ICP22 of Herpes Simplex Virus 1 Decreases RNA Polymerase Processivity

Published:2022-03-09 Issue:5 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Birkenheuer Claire H.¹²^ORCID,Dunn Laura¹²,Dufour Rachel²,Baines Joel D.¹²^ORCID

Affiliation:

1. Baker Institute of Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA

2. Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA

Abstract

The longstanding observation that ICP22 reduces RNA polymerase II (Pol II) serine 2 phosphorylation, which initiates transcriptional elongation, is puzzling because this phosphorylation is essential for viral replication. The current study helps explain this apparent paradox because it demonstrates significant advantages in negatively regulating transcriptional elongation, including the reduction of antisense and intergenic transcription.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.02191-21

Reference46 articles.

1. Initiation of transcription and RNA synthesis, processing and transport in HSV and VZV infected cells

2. Regulation of Herpesvirus Macromolecular Synthesis I. Cascade Regulation of the Synthesis of Three Groups of Viral Proteins

3. Viral DNA synthesis is required for the efficient expression of specific herpes simplex virus type 1 mRNA species