The Attenuated Pseudorabies Virus Vaccine Strain Bartha Hyperactivates Plasmacytoid Dendritic Cells by Generating Large Amounts of Cell-Free Virus in Infected Epithelial Cells

Author:

Delva Jonas L.1,Van Waesberghe Cliff1,Van Den Broeck Wim2,Lamote Jochen A.3,Vereecke Nick1ORCID,Theuns Sebastiaan1,Couck Liesbeth2,Favoreel Herman W.1ORCID

Affiliation:

1. Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium

2. Department of Morphology, Imaging, Orthopedics, Rehabilitation and Nutrition, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium

3. VIB-KULeuven Center for Cancer Biology, VIB FACS Expertise Center, Leuven, Belgium

Abstract

The pseudorabies virus (PRV) vaccine strain Bartha has been and still is critical in the eradication of PRV in numerous countries. However, little is known about how this vaccine strain interacts with host cells and the host immune system.

Funder

F.W.O.-Vlaanderen

Special Research Fund - Ghent University

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference93 articles.

1. Molecular Biology of Pseudorabies Virus: Impact on Neurovirology and Veterinary Medicine

2. Mettenleiter TC, Ehlers B, Müller T, Yoon K-J, Teifke JP. 2012. Viral diseases, herpesviruses, p 421–434. In Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW (ed), Diseases of swine, 11th ed. John Wiley & Sons, Chichester, United Kingdom.

3. An economic assessment of pseudorabies (Aujeszky’ disease) elimination on hog farms in China

4. Vaccines against pseudorabies virus (PrV)

5. Experiments to reduce the virulence of Aujeskzy’s virus;Bartha A;Magy Allatorvosok Lapja,1961

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