The Attenuated Pseudorabies Virus Vaccine Strain Bartha Hyperactivates Plasmacytoid Dendritic Cells by Generating Large Amounts of Cell-Free Virus in Infected Epithelial Cells-Reference-Cited by-同舟云学术

The Attenuated Pseudorabies Virus Vaccine Strain Bartha Hyperactivates Plasmacytoid Dendritic Cells by Generating Large Amounts of Cell-Free Virus in Infected Epithelial Cells

Published:2022-06-22 Issue:12 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Delva Jonas L.¹,Van Waesberghe Cliff¹,Van Den Broeck Wim²,Lamote Jochen A.³,Vereecke Nick¹^ORCID,Theuns Sebastiaan¹,Couck Liesbeth²,Favoreel Herman W.¹^ORCID

Affiliation:

1. Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium

2. Department of Morphology, Imaging, Orthopedics, Rehabilitation and Nutrition, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium

3. VIB-KULeuven Center for Cancer Biology, VIB FACS Expertise Center, Leuven, Belgium

Abstract

The pseudorabies virus (PRV) vaccine strain Bartha has been and still is critical in the eradication of PRV in numerous countries. However, little is known about how this vaccine strain interacts with host cells and the host immune system.

Funder

F.W.O.-Vlaanderen

Special Research Fund - Ghent University

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.02199-21

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