FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair-Reference-Cited by-同舟云学术

FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair

Published:2021-08-24 Issue:9 Volume:41 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Kratz Katja¹,Artola-Borán Mariela¹,Kobayashi-Era Saho¹²,Koh Gene³⁴⁵,Oliveira Goncalo⁶,Kobayashi Shunsuke¹²,Oliveira Andreia¹²,Zou Xueqing³⁴⁵,Richter Julia²,Tsuda Masataka⁷,Sasanuma Hiroyuki⁷,Takeda Shunichi⁷,Loizou Joanna I.⁶,Sartori Alessandro A.¹,Nik-Zainal Serena⁴⁵,Jiricny Josef¹²^ORCID

Affiliation:

1. Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland

2. Institute of Biochemistry of the ETH Zurich, Zurich, Switzerland

3. Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom

4. Academic Department of Medical Genetics, The Clinical School, University of Cambridge, Cambridge, United Kingdom

5. MRC Cancer Unit, The Clinical School, University of Cambridge, Cambridge, United Kingdom

6. Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria

7. Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Abstract

Germline mutations in the mismatch repair (MMR) genes MSH2 , MSH6 , MLH1 , and PMS2 are linked to cancer of the colon and other organs, characterized by microsatellite instability and a large increase in mutation frequency. Unexpectedly, mutations in EXO1 , encoding the only exonuclease genetically implicated in MMR, are not linked to familial cancer and cause a substantially weaker mutator phenotype.

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00303-21

Reference70 articles.

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4. MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2

5. GTBP, a 160-Kilodalton Protein Essential for Mismatch-binding Activity in Human Cells

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