Affiliation:
1. Integrated Toxicology
2. Bacteriology Divisions, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702-5011
Abstract
ABSTRACT
Various in vitro effects of staphylococcal enterotoxin B (SEB) on human peripheral blood mononuclear cells were mitigated by
Bacillus anthracis
edema toxin. In particular, levels of some SEB-induced cytokines (tumor necrosis factor alpha, gamma interferon) and chemokines (monocyte chemoattractant protein 1, macrophage inflammatory protein 1 alpha [MIP-1α], MIP-1β) were significantly diminished or even nonexistent, depending upon the timing of edema toxin administration. Overall, these results suggest a novel use of
B. anthracis
edema toxin against a bacterial superantigen.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
4 articles.
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