Impaired Kupffer Cells in Highly Susceptible Mice Infected with Trypanosoma congolense-Reference-Cited by-同舟云学术

Impaired Kupffer Cells in Highly Susceptible Mice Infected with Trypanosoma congolense

Published:2005-12 Issue:12 Volume:73 Page:8393-8396
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Shi Meiqing¹,Wei Guojian¹,Pan Wanling¹,Tabel Henry¹

Affiliation:

1. Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada

Abstract

ABSTRACT In highly susceptible BALB/c mice infected with Trypanosoma congolense , the total number of Kupffer cells in the liver remains constant; however, their mean size increases fivefold towards the terminal stage. About 25% of Kupffer cells undergo apoptosis. We suggest that development of an impairment of the macrophage system might be a major mechanism for inefficient elimination of trypanosomes.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.73.12.8393-8396.2005

Reference28 articles.

1. Cross, G. A. 1990. Cellular and genetic aspects of antigenic variation in trypanosomes. Annu. Rev. Immunol.8:83-110.

2. Dempsey, W. L., and J. M. Mansfield. 1983. Lymphocyte function in experimental African trypanosomiasis. V. Role of antibody and the mononuclear phagocyte system in variant-specific immunity. J. Immunol.130:405-411.

3. Freire-de-Lima, C. G., M. P. Nunes, S. Corte-Real, M. P. Soares, J. O. Previato, L. Mendonca-Previato, and G. A. DosReis. 1998. Proapoptotic activity of a Trypanosoma cruzi ceramide-containing glycolipid turned on in host macrophages by IFN-gamma. J. Immunol.161:4909-4916.

4. Fukuda, R., N. Ishimura, T. X. Nguyen, A. Chowdhury, S. Ishihara, N. Kohge, S. Akagi, M. Watanabe, and S. Fukumoto. 1995. The expression of IL-2, IL-4 and interferon-gamma (IFN-gamma) mRNA using liver biopsies at different phases of acute exacerbation of chronic hepatitis B. Clin. Exp. Immunol.100:446-451.

5. Galle, P. R., W. J. Hofmann, H. Walczak, H. Schaller, G. Otto, W. Stremmel, P. H. Krammer, and L. Runkel. 1995. Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J. Exp. Med.182:1223-1230.

Cited by 20 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cytokines profile of mice infected by high and low virulences of Indonesian T. evansi isolates;Jurnal Ilmu Ternak dan Veteriner;2018-03-02

2. Interferon Gamma in African Trypanosome Infections: Friends or Foes?;Frontiers in Immunology;2017-09-07

3. African Trypanosomiasis as Paradigm for Involvement of the Mononuclear Phagocyte System in Pathogenicity During Parasite Infection;Macrophages: Biology and Role in the Pathology of Diseases;2014

4. Adaptive Immunity and Trypanosomiasis-Driven B-Cell Destruction;Trypanosomes and Trypanosomiasis;2013-08-22

5. Current status of vaccination against African trypanosomiasis;Parasitology;2010-05-05