Tissue Inhibitor of Metalloproteinase 1 Regulates Resistance to Infection-Reference-Cited by-同舟云学术

Tissue Inhibitor of Metalloproteinase 1 Regulates Resistance to Infection

Published:2005-01 Issue:1 Volume:73 Page:661-665
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Lee Marie Mei¹,Yoon Bong-June¹,Osiewicz Keith¹,Preston Michael²,Bundy Brian¹,van Heeckeren Anna M.³,Werb Zena⁴,Soloway Paul D.¹⁵

Affiliation:

1. Roswell Park Cancer Institute, Buffalo

2. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts

3. Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio

4. Department of Anatomy, University of California, San Francisco, California

5. Division of Nutritional Sciences, Cornell University, Ithaca, New York

Abstract

ABSTRACT Tissue inhibitor of metalloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.73.1.661-665.2005

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