Respiratory Vaccination with Hemagglutinin Nanoliposomes Protects Mice from Homologous and Heterologous Strains of Influenza Virus-Reference-Cited by-同舟云学术

Respiratory Vaccination with Hemagglutinin Nanoliposomes Protects Mice from Homologous and Heterologous Strains of Influenza Virus

Published:2022-10-12 Issue:19 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Sia Zachary R.¹,Chiem Kevin²³,Huang Wei-Chiao¹,Seffouh Amal⁴,Teimouri Dereshgi Amir⁵⁶,Hogan Tara⁵⁶,Ortega Joaquin⁴,Davidson Bruce A.⁵⁶^ORCID,Martinez-Sobrido Luis²³^ORCID,Lovell Jonathan F.¹^ORCID

Affiliation:

1. Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York, USA

2. Texas Biomedical Research Institute, San Antonio, Texas, USA

3. Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA

4. Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada

5. Veterans Administration Western New York Healthcare System, Buffalo, New York, USA

6. Department of Anesthesiology, University at Buffalo, State University of New York, Buffalo, New York, USA

Abstract

A self-assembling influenza virus vaccine platform that seamlessly converts soluble antigens into nanoparticles is demonstrated with various H1N1 and H3N2 influenza antigens to protect mice against influenza virus challenge following intranasal vaccination. Mucosal immune responses following liposome delivery to lung antigen-presenting cells are demonstrated.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01006-22

Reference37 articles.

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