Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy-Reference-Cited by-同舟云学术

Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy

Published:1996-06 Issue:2 Volume:60 Page:301-315
ISSN:0146-0749
Container-title:Microbiological Reviews
language:en
Short-container-title:Microbiol Rev

Author:

Meshnick S R¹,Taylor T E¹,Kamchonwongpaisan S¹

Affiliation:

1. Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor 48109-2029, USA. meshnick@umich.edu

Abstract

Artemisinin and its derivatives are endoperoxide-containing compounds which represent a promising new class of antimalarial drugs. In the presence of intraparasitic iron, these drugs are converted into free radicals and other electrophilic intermediates which then alkylate specific malaria target proteins. Combinations of available derivatives and other antimalarial agents show promise both as first-line agents and in the treatment of severe disease.

Publisher

American Society for Microbiology

Subject

Applied Microbiology and Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/mr.60.2.301-315.1996

Reference197 articles.

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