Comparative In Vitro Activity of Five Cephalosporins Against Lactobacilli

Author:

Bayer Arnold S.12,Chow Anthony W.12,Concepcion Nelydia F.12,Guze Lucien B.12

Affiliation:

1. Department of Medicine, Harbor General Hospital, Torrance, California 90502

2. Research and Medical Services, Wadsworth Veterans Administration Hospital, and School of Medicine, University of California at Los Angeles, Los Angeles, California 90073

Abstract

Of five parenteral cephalosporins tested against 43 lactobacilli, cephaloridine, cefazolin, and cefamandole were the most active inhibitory and bactericidal agents. Timed-kill analysis revealed a slow bactericidal effect, with significant declines in mean minimal bactericidal concentration values at 48 h versus 24 h.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference12 articles.

1. Endocarditis caused by Lactobacillus plantarum;Axelrod J.;Ann. Intern. Med.,1973

2. Lactobacillemia-report of nine cases;Bayer A. S.;Am. J. Med.,1978

3. Susceptibility of 40 lactobacilli to six antimicrobial agents with broad gram-positive anaerobic spectra;Bayer A. S.;Antimicrob. Agents Chemother.,1978

4. Cunha B. A. H. R. Gossling H. S. Pasternak C. H. Nightingdale and R. Quintiliani. 1971. The penetration characteristics of cefazolin cephalothin and cepharidine into bone in patients undergoing total hip replacement. J. Bone Joint Surg. 59-A:856-859.

5. Holdeman L. V. and W. E. C. Moore. 1973. Anaerobic gram-positive non-sporing rods p. 000-000. In Anaerobe laboratory manual. Southern Printing Co. Blacksburg Virginia.

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