Affiliation:
1. Department of Microbiology, School of Medicine, Gunma University, Maebashi, Japan
Abstract
A histidine auxotroph (
his
−) of
Staphylococcus aureus
MS3937 and mutants sensitive to ultraviolet (UV) irradiation were obtained. The UV-sensitive mutants were found also to be sensitive to
N
-methyl-
N
′-nitro-
N
-nitrosoguanidine and mitomycin C, and their sensitivity was accounted for by a defect in deoxyribonucleic acid repair. Transduction of either chromosomal or plasmid markers to UV-sensitive mutants showed that these staphylococcus mutants are of the
recA
(reckless) type mutants as reported in
Escherichia coli
and
Salmonella typhimurium;
therefore the UV-sensitive mutants (
uvr
−) were renamed recombination-deficient mutants (
rec
−). The biochemical and genetic properties of these mutants are described, and their usefulness for studies of staphylococcal plasmids is discussed.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
17 articles.
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1. DNA Repair Systems;Bacillus subtilis and Other Gram-Positive Bacteria;2014-04-30
2. DNA Repair and Genome Maintenance in Bacillus subtilis;Microbiology and Molecular Biology Reviews;2012-09
3. A GENETIC STUDY OF INDUCIBLE ERYTHROMYCIN RESISTANCE IN STAPHYLOCOCCUS AUREUS;Acta Pathologica Microbiologica Scandinavica Section B Microbiology and Immunology;2009-08-15
4. Recombination-Deficient Mutants of an Extreme Thermophile,
Thermus thermophilus;Applied and Environmental Microbiology;1993-08
5. The RecA Protein: Structure and Functio;Critical Reviews in Biochemistry and Molecular Biology;1990-01