Antibody Responses to Haemophilus influenzae Type b and Diphtheria Toxin Induced by Conjugates of Oligosaccharides of the Type b Capsule with the Nontoxic Protein CRM 197-Reference-Cited by-同舟云学术

Antibody Responses to Haemophilus influenzae Type b and Diphtheria Toxin Induced by Conjugates of Oligosaccharides of the Type b Capsule with the Nontoxic Protein CRM 197

Published:1983-01 Issue:1 Volume:39 Page:233-238
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Anderson Porter¹

Affiliation:

1. Departments of Pediatrics and Microbiology, University of Rochester Medical Center, Rochester, New York 14642

Abstract

Oligosaccharides were made from Haemophilus influenzae type b capsular polysaccharide and conjugated to CRM 197 by reductive amination. Conjugates were made with a range of lengths and multiplicities of saccharide chains. All elicited a strongly enhanced anti- H. influenzae type b capsular polysaccharide response when injected into weanling rabbits. One series of conjugates also elicited antibodies to diphtheria toxin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.39.1.233-238.1983

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