Impact of Bicarbonate on PBP2a Production, Maturation, and Functionality in Methicillin-Resistant Staphylococcus aureus-Reference-Cited by-同舟云学术

Impact of Bicarbonate on PBP2a Production, Maturation, and Functionality in Methicillin-Resistant Staphylococcus aureus

Published:2021-04-19 Issue:5 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ersoy Selvi C.¹^ORCID,Chambers Henry F.²,Proctor Richard A.³,Rosato Adriana E.⁴,Mishra Nagendra N.¹⁵,Xiong Yan Q.¹⁵,Bayer Arnold S.¹⁵

Affiliation:

1. The Lundquist Institute, Torrance, California, USA

2. UCSF School of Medicine, San Francisco, California, USA

3. Departments of Medicine and Medical Microbiology/Immunology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

4. Department of Pathology, Riverside University Health Systems, Riverside, California, USA

5. Geffen School of Medicine at UCLA, Los Angeles, California, USA

Abstract

Certain methicillin-resistant Staphylococcus aureus (MRSA) strains exhibit β-lactam susceptibility in vitro , ex vivo , and in vivo in the presence of NaHCO 3 (NaHCO 3 -responsive MRSA). Here, we investigate the impact of NaHCO 3 on factors required for PBP2a functionality.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02621-20

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