Author:
Williams M E,Thomas D,Harman C P,Mintz P D,Donowitz G R
Abstract
Clavulanic acid, a beta-lactamase inhibitor, was found to be associated with the development of a positive direct antiglobulin test. Of 23 antibiotic courses in patients treated with ticarcillin, clavulanic acid, and tobramycin, 10 (43.5%) developed positive direct antiglobulin tests versus 2 of 26 (7.7%) patients treated with piperacillin and tobramycin (P = 0.0044). In vitro immunohematological studies showed that clavulanic acid caused a nonimmunologic adsorption of plasma proteins onto the erythrocyte surface. Hemolysis was not associated with such nonimmunologic adsorption. However, the resulting positive antiglobulin test might delay cross matching of blood products for transfusions or interfere with the evaluation of true immune-mediated hemolytic anemia.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference6 articles.
1. Edberg S. C. and L. D. Sabath. 1980. Determination of antibiotic levels in body fluids: techniques and significance. Bactericidal tests in endocarditis and other severe infections p. 223-225. In V. Lorian (ed.) Antibiotics in laboratory medicine. The Williams & Wilkins Co. Baltimore.
2. Drug-induced immune hemolytic anemia;Garratty G.;Am. J. Med.,1975
3. Coombs' positive reactions associated with sodium cephalothin therapy;Gralnick H. R.;J. Am. Med. Assoc.,1967
4. Methyldopa inhibition of suppressor-lymphocyte function. A proposed cause of autoimmune hemolytic anemia;Kirtland H. H.;N. Engl. J. Med.,1980
5. Positive direct Coombs tests due to cephalothin;Molthan L.;N. Engl. J. Med.,1967
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