A Fungal P450 Enzyme from Fusarium graminearum with Unique 12β-Steroid Hydroxylation Activity

Author:

Wang Ling1,Wu Xiaowei2,Gao Chenghua1,Wei Lingrui1,Li Qian1,Li Aitao1ORCID

Affiliation:

1. State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan, People’s Republic of China

2. Department of Thoracic Surgery, Tongji Hospital, Tongji Medical Collage of Huazhong University of Science and Technology, Wuhan, People’s Republic of China

Abstract

Regioselective and stereoselective hydroxylation is of vital importance in the functionalization of steroids, which remains challenging in organic synthesis. In particular, the C12-hydroxy steroids play a significant role in the synthesis of many important steroidal drugs.

Funder

The Natural Science Foundation of Hubei University

The Innovation Base for Introducing Talents of Discipline of Hubei Province

Research Program of State Key Laboratory of Biocatalysis and Engineering

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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