Prevalence and Molecular Diversity of Hepatitis B Virus and Hepatitis Delta Virus in Urban and Rural Populations in Northern Gabon in Central Africa

Author:

Makuwa Maria1,Mintsa-Ndong Armel1,Souquière Sandrine1,Nkoghé Dieudonné2,Leroy Eric M.2,Kazanji Mirdad134

Affiliation:

1. Unité de Virologie

2. Unité de Maladies Émergentes, Centre International de Recherches Médicales de Franceville (CIRMF), BP 769 Franceville, Gabon

3. Service de Coopération et d'Action Culturelle, French Embassy, BP 2105 Libreville, Gabon

4. Réseau International des Instituts Pasteur, Institut Pasteur, 28 rue du Dr Roux, Paris, France

Abstract

ABSTRACT The prevalence of hepatitis B virus (HBV) surface antigen was significantly higher in urban (12.9%) than in rural (7.6%) populations ( P = 0.003), but no difference was found in the prevalence of hepatitis delta virus (HDV), which was high in both populations. Phylogenetic analysis showed the circulation of HBV-A3 and -E genotypes and the presence of HDV-1, HDV-7, and HDV-8 clades.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference12 articles.

1. Hou, J., Z. Liu, and F. Gu. 2005. Epidemiology and prevention of hepatitis B virus infection. Int. J. Med. Sci.2:50-57.

2. Husa, P., A. Linhartova, V. Nemecek, and L. Husova. 2005. Hepatitis D. Acta Virol.49:219-225.

3. Journal Officiel de la République Gabonaise. 2005. Recensements de la Republique Gabonaise, p. 15-16. InJournal Officiel de la Republique Gabonaise, vol. 46. Direction Generale des Publications Officielles, Libreville, Gabon.

4. Kramvis, A., and M. C. Kew. 2007. Epidemiology of hepatitis B virus in Africa, its genotypes and clinical associations of genotypes. Hepatol. Res.37:S9-S19.

5. Kurbanov, F., Y. Tanaka, K. Fujiwara, F. Sugauchi, D. Mbanya, L. Zekeng, N. Ndembi, C. Ngansop, L. Kaptue, T. Miura, E. Ido, M. Hayami, H. Ichimura, and M. Mizokami. 2005. A new subtype (subgenotype) Ac (A3) of hepatitis B virus and recombination between genotypes A and E in Cameroon. J. Gen. Virol.86:2047-2056.

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