PSMD12-Mediated M1 Ubiquitination of Influenza A Virus at K102 Regulates Viral Replication-Reference-Cited by-同舟云学术

PSMD12-Mediated M1 Ubiquitination of Influenza A Virus at K102 Regulates Viral Replication

Published:2022-08-10 Issue:15 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Hui Xianfeng¹²,Cao Lei¹²,Xu Ting¹²,Zhao Lianzhong¹²,Huang Kun¹²,Zou Zhong¹²³,Ren Peilei¹²,Mao Haiying¹²,Yang Ying¹²³,Gao Shuo¹²,Sun Xiaomei¹²,Lin Xian¹²,Jin Meilin¹²³⁴^ORCID

Affiliation:

1. State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China

2. College of Animal Medicine, Huazhong Agricultural University, Wuhan, China

3. Key Laboratory of development of veterinary diagnostic products, Ministry of Agriculture, Wuhan, Hubei, People’s Republic of China

4. The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China

Abstract

M1 is proposed to play multiple biologically important roles in the life cycle of IAV, which relies largely on host factors. This study is the first one to identify that PSMD12 interacts with M1, mediates K63-linked ubiquitination of M1 at the K102 site, and thus positively regulates influenza virus proliferation.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00786-22

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