FKS2 Mutations Associated with Decreased Echinocandin Susceptibility of Candida glabrata following Anidulafungin Therapy-Reference-Cited by-同舟云学术

FKS2 Mutations Associated with Decreased Echinocandin Susceptibility of Candida glabrata following Anidulafungin Therapy

Published:2011-03 Issue:3 Volume:55 Page:1312-1314
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Costa-de-Oliveira Sofia¹²,Marcos Miranda Isabel¹²,Silva Raquel M.³,Pinto e Silva Ana¹²,Rocha Rita¹,Amorim António³⁴,Gonçalves Rodrigues Acácio¹²⁵,Pina-Vaz Cidália¹²⁶

Affiliation:

1. Department of Microbiology, Faculty of Medicine, Porto University, Alameda Prof. Hernani Monteiro, 4200 Porto, Portugal

2. Cardiovascular Research & Development Unit, Faculty of Medicine, Porto University, Porto, Portugal

3. IPATIMUP—Institute of Molecular Pathology and Immunology of Porto University, Rua Dr. Roberto Frias s/n, 4200-465 Porto, Portugal

4. Faculty of Sciences, Porto University, Pr. Gomes Teixeira, 4099-002 Porto, Portugal

5. Burn Unit, Department of Plastic and Reconstructive Surgery, Hospital S. João, Porto, Portugal

6. Department of Microbiology, Hospital S. João, Porto, Portugal

Abstract

ABSTRACT This is the first case report of Candida glabrata -disseminated candidiasis describing the acquisition of echinocandin resistance following anidulafungin treatment. The initial isolates recovered were susceptible to echinocandins. However, during 27 days of anidulafungin treatment, two resistant strains were isolated (from the blood and peritoneal fluid). The resistant peritoneal fluid isolate exhibited a Ser663Pro mutation in position 1987 of FKS2 HS1 (hot spot 1), whereas the resistant blood isolate displayed a phenylalanine deletion (Phe659).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00589-10

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