Affiliation:
1. Eastern New Mexico University, Department of Biology, Portales, New Mexico 88130
Abstract
ABSTRACT
A multidrug efflux pump designated LmrS (lincomycin resistance protein of
Staphylococcus aureus
), belonging to the major facilitator superfamily (MFS) of transporters, was cloned, and the role of LmrS in antimicrobial efflux was evaluated. The highest relative increase in MIC, 16-fold, was observed for linezolid and tetraphenylphosphonium chloride (TPCL), followed by an 8-fold increase for sodium dodecyl sulfate (SDS), trimethoprim, and chloramphenicol. LmrS has 14 predicted membrane-spanning domains and is homologous to putative lincomycin resistance proteins of
Bacillus
spp.,
Lactobacillus
spp., and
Listeria
spp.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
150 articles.
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