Histone Modifications in Papillomavirus Virion Minichromosomes

Author:

Porter Samuel S.12,Liddle Jennifer C.345,Browne Kristen6,Pastrana Diana V.7ORCID,Garcia Benjamin A.38,Buck Christopher B.7ORCID,Weitzman Matthew D.345,McBride Alison A.1ORCID

Affiliation:

1. Laboratory of Viral Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

2. Biological Science Graduate Program, University of Maryland, College Park, Maryland, USA

3. Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

4. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

5. Division of Protective Immunity and Division of Cancer Pathobiology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

6. Bioinformatics and Computational Biosciences Branch (BCBB), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

7. Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

8. Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

A relatively unique feature of papillomaviruses is that the viral genome is associated with host histones inside the virion. However, little is known about the nature of the epigenome within papillomavirions or its biological relevance to the infectious viral cycle.

Funder

HHS | NIH | National Cancer Institute

HHS | National Institutes of Health

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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