Alterations in Vaginal Microbiota and Associated Metabolome in Women with Recurrent Implantation Failure

Author:

Fu Min12,Zhang Xiaowei3,Liang Yiheng1,Lin Shouren2,Qian Weiping2,Fan Shangrong14

Affiliation:

1. Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China

2. Department of Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China

3. BGI-Shenzhen, Shenzhen, Guangdong, China

4. Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecological Disease, Shenzhen, Guangdong, China

Abstract

In vitro fertilization-embryo transfer (IVF-ET) is now widely applied for treating infertility, and unexplained recurrent implantation failure (RIF) has become a substantial challenge. We hypothesize that vaginal microbial dysbiosis is associated with RIF, as it is linked to many female reproductive diseases. In this study, we characterized the vaginal microbiota and metabolomes of patients with unexplained RIF, while patients who achieved clinical pregnancy in the first IVF cycle were set as controls. In general, significant differences were discovered in the vaginal microbiota and metabolomes between the two groups. This study is the first detailed elaboration of the vaginal microbiota and metabolites associated with RIF. We believe that our findings will inspire researchers to consider the dynamics of microbiomes related to the microenvironment as a critical feature for future studies of nosogenesis not only for RIF but also for other reproductive diseases.

Funder

Shenzhen Municipal Government

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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