Effect of ganciclovir [9-(1,3-dihydroxy-2-propoxymethyl)guanine] on viral DNA and protein synthesis in cells infected with herpes simplex virus-Reference-Cited by-同舟云学术

Effect of ganciclovir [9-(1,3-dihydroxy-2-propoxymethyl)guanine] on viral DNA and protein synthesis in cells infected with herpes simplex virus

Published:1987-02 Issue:2 Volume:31 Page:349-351
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chun Y S,Park N H

Abstract

The effect of ganciclovir [9-(1,3-dihydroxy-2-propoxymethyl)guanine] on herpes simplex virus type 1 DNA and protein synthesis was studied. Ganciclovir markedly inhibited the synthesis of viral DNA and gamma proteins in a dose-dependent manner. However, the synthesis of viral beta proteins was significantly increased by ganciclovir in the later stage of infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.31.2.349

Reference16 articles.

1. Activation by thymidine kinase and potent antiherpetic activity of 2'-nor-2'-deoxyguanosine (2'NDG);Ashton W. T.;Biochem. Biophys. Res. Commun.,1982

2. Molecular genetics of herpes simplex virus. VII. Characterization of a temperature-sensitive mutant produced by in vitro mutagenesis and defective in DNA synthesis and accumulation of -y polypeptides;Conley A. J.;J. Virol.,1981

3. 9-[[2-Hydroxy-1-(hydroxymethyl) ethoxylmethyl]guanine: a selective inhibitor of herpes group virus replication;Field A. K.;Proc. Natl. Acad. Sci. USA,1983

4. Interaction of herpes simplex virus-induced DNA polymerase with 9-(1,3- dihydroxy-2-propoxymethyl)guanine triphosphate;Frank K. B.;J. Biol. Chem.,1984

5. Effect of acyclovir on viral protein synthesis in cells infected with herpes simplex virus type 1;Furman P. A.;Antimicrob. Agents Chemother.,1983

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