The Antimalarial Trioxaquine DU1301 Alkylates Heme in Malaria-Infected Mice-Reference-Cited by-同舟云学术

The Antimalarial Trioxaquine DU1301 Alkylates Heme in Malaria-Infected Mice

Published:2008-08 Issue:8 Volume:52 Page:2966-2969
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bousejra-El Garah Fatima¹,Claparols Catherine¹,Benoit-Vical Françoise¹²,Meunier Bernard³,Robert Anne¹

Affiliation:

1. Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, 31077 Toulouse Cedex 4, France

2. Service de Parasitologie et Mycologie, CHU Rangueil, Université de Toulouse, TSA 50032, 31059 Toulouse Cedex 9, France

3. Palumed, rue Pierre et Marie Curie, BP 28262, 31682 Labège Cedex, France

Abstract

ABSTRACT The in vivo alkylation of heme by the antimalarial trioxaquine DU1301 afforded covalent heme-drug adducts that were detected in the spleens of Plasmodium sp.-infected mice. This result indicates that the alkylation capacities of trioxaquines in mammals infected with Plasmodium strains are similar to that of artemisinin, a natural antimalarial trioxane-containing drug.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00165-08

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