Sequencing and Comparative Genomic Analysis of pK29, a 269-Kilobase Conjugative Plasmid Encoding CMY-8 and CTX-M-3 β-Lactamases in Klebsiella pneumoniae-Reference-Cited by-同舟云学术

Sequencing and Comparative Genomic Analysis of pK29, a 269-Kilobase Conjugative Plasmid Encoding CMY-8 and CTX-M-3 β-Lactamases in Klebsiella pneumoniae

Published:2007-08 Issue:8 Volume:51 Page:3004-3007
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chen Ying-Tsong¹,Lauderdale Tsai-Ling²,Liao Tsai-Lien¹,Shiau Yih-Ru²,Shu Hung-Yu³,Wu Keh-Ming¹⁴,Yan Jing-Jou⁵,Su Ih-Jen²,Tsai Shih-Feng¹³⁴⁶⁷

Affiliation:

1. Division of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan

2. Division of Clinical Research, National Health Research Institutes, Zhunan, Miaoli, Taiwan

3. Genome Research Center, National Yang-Ming University, Taipei, Taiwan

4. Institute of Bioinformatics, National Yang-Ming University, Taipei, Taiwan

5. Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan

6. Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan

7. Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan

Abstract

ABSTRACT A 269-kilobase conjugative plasmid, pK29, from a Klebsiella pneumoniae strain was sequenced. The plasmid harbors multiple antimicrobial resistance genes, including those encoding CMY-8 AmpC-type and CTX-M-3 extended-spectrum β-lactamases in the common backbone of IncHI2 plasmids. Mechanisms for dissemination of the resistance genes are highlighted in comparative genomic analyses.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00167-07

Reference27 articles.

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