Author:
Winkelstein J A,Swift A J
Abstract
Resistance to pneumococcal infection was tested in T-lymphocyte-deficient, nude (nu/nu) mice. Pneumococcal serum opsonizing activity, in vivo phagocytosis of the pneumococcus, and the mean lethal dose for the pneumococcus were all found to be the same in nude mice as in control (+/+) mice. T-lymphocytes do not appear to play a significant role in the host's defense against the pneumococcus.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference13 articles.
1. Evidence for the existence of two functionally distinct types of cells which regulate the antibody response to type III pneumococcal polysaccharide;Baker P. J.;J. Immunol.,1970
2. Congenital aplasia of the thymus gland (Di-Georges Syndrome);Kretschmer R.;N. Engl. J. Med.,1968
3. Effects of C-reactive protein on the Iymphoid system. I. Binding to thymus-dependent Iymphocytes and alteration of their functions;Mortensen R. F.;J. Exp. Med.,1975
4. Absence of thymus in a mouse mutant;Pantelouris E. M.;Nature (London),1968
5. Observations on the immunobiology of 'nude" mice;Pantelouris E. M.;Immunology,1971
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