The Naturally Attenuated Kunjin Strain of West Nile Virus Shows Enhanced Sensitivity to the Host Type I Interferon Response-Reference-Cited by-同舟云学术

The Naturally Attenuated Kunjin Strain of West Nile Virus Shows Enhanced Sensitivity to the Host Type I Interferon Response

Published:2011-06 Issue:11 Volume:85 Page:5664-5668
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Daffis Stephane¹,Lazear Helen M.¹,Liu Wen Jun²,Audsley Michelle²³,Engle Michael¹,Khromykh Alexander A.²,Diamond Michael S.¹⁴⁵

Affiliation:

1. Departments of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110

2. Australian Infectious Disease Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia

3. Present address: Monash University, Melbourne, VIC, Australia.

4. Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110

5. Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri 63110

Abstract

ABSTRACT The host determinants that contribute to attenuation of the naturally occurring nonpathogenic strain of West Nile virus (WNV), the Kunjin strain (WNV KUN ), remain unknown. Here, we show that compared to a highly pathogenic North American strain, WNV KUN exhibited an enhanced sensitivity to the antiviral effects of type I interferon. Our studies establish that the virulence of WNV KUN can be restored in cells and mice deficient in specific interferon regulatory factors (IRFs) or the common type I interferon receptor. Thus, WNV KUN is attenuated primarily through its enhanced restriction by type I interferon- and IRF-3-dependent mechanisms.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00232-11

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