Biliary excretion of platinum in a patient treated with cis-dichlorodiammineplatinum (II)

Author:

Shelley M D,Fish R G,Adams M

Abstract

Biliary excretion of platinum was measured in a patient receiving an intravenous infusion of cis-dichlorodiammineplatinum (II). Over a 3-day period, less than 1% of the administered platinum was detected in the bile, and 47% appeared in the urine, indicating that biliary excretion is a minor route of elimination.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference7 articles.

1. Platinum concentrations in bile and plasma following rapid and 6 hour infusions of cis-dichlorodiammineplatinum (II);Casper E. S.;Cancer Treat. Rep.,1979

2. DeSimone P. A. R. S. Yancey J. J. Coupal J. D. Butts and J. D. Hoeschel. 1979. Effect of a forced diuresis on the distribution and excretion (via urine and bile) of 195mplatinum when given

3. NOTES

4. Total body clearance and platinum accumulation in patients treated with cis-dichlorodiammineplatinum (II);Fish R. G.;Ther. Drug Monit.,1984

5. Pharmacokinetics and protein binding of cis-dichlorodiammineplatinum (II) administered as a one hour or as a twenty hour infusion;Gullo J. J.;Cancer Chemother. Pharmacol.,1980

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