Characterization of the Serpentine Adeno-Associated Virus (SAAV) Capsid Structure: Receptor Interactions and Antigenicity-Reference-Cited by-同舟云学术

Characterization of the Serpentine Adeno-Associated Virus (SAAV) Capsid Structure: Receptor Interactions and Antigenicity

Published:2022-06-08 Issue:11 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Mietzsch Mario¹,Hull Joshua A.¹,Makal Victoria E.¹,Jimenez Ybargollin Alberto¹,Yu Jennifer C.¹,McKissock Kedrick¹,Bennett Antonette¹,Penzes Judit¹,Lins-Austin Bridget¹,Yu Qian²,Chipman Paul¹,Bhattacharya Nilakshee³,Sousa Duncan³,Strugatsky David⁴,Tijssen Peter²,McKenna Robert¹^ORCID,Agbandje-McKenna Mavis¹^ORCID

Affiliation:

1. University of Florida, Department of Biochemistry & Molecular Biology, Gainesville, Florida, USA

2. NRS-Institut Armand Frappier, Université du Québec, Laval, Quebec, Canada

3. Biological Science Imaging Resource, Department of Biological Sciences, Florida State University, Tallahassee, Florida, USA

4. David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA

Abstract

AAVs are widely studied therapeutic gene delivery vectors. However, preexisting antibodies and their detrimental effect on therapeutic efficacy are a primary challenge encountered during clinical trials.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00335-22

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3. Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues