Expression and Self-Assembly of Norwalk Virus Capsid Protein from Venezuelan Equine Encephalitis Virus Replicons-Reference-Cited by-同舟云学术

Expression and Self-Assembly of Norwalk Virus Capsid Protein from Venezuelan Equine Encephalitis Virus Replicons

Published:2002-03-15 Issue:6 Volume:76 Page:3023-3030
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Baric Ralph S.¹²,Yount Boyd¹,Lindesmith Lisa¹,Harrington Patrick R.²,Greene Shermalyn R.¹,Tseng Fan-Chen¹,Davis Nancy²,Johnston Robert E.²,Klapper David G.²,Moe Christine L.¹

Affiliation:

1. Department of Epidemiology, Program in Infectious Diseases, School of Public Health

2. Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7400

Abstract

ABSTRACT The Norwalk virus (NV) capsid protein was expressed using Venezuelan equine encephalitis virus replicon particles (VRP-NV1). VRP-NV1 infection resulted in large numbers of recombinant NV-like particles that were primarily cell associated and were indistinguishable from NV particles produced from baculoviruses. Mutations located in the N-terminal and P1 domains of the NV capsid protein ablated capsid self-assembly in mammalian cells.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.76.6.3023-3030.2002

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