Abstract
Escherichia coli septicemia is a common disease of young poultry and several species of mammals. Rabbit antiserum was prepared against iron-regulated outer membrane proteins of E. coli. Eighteen-day-old turkeys were passively immunized with antiserum and challenged by air sac inoculation of 1 X 10(6) to 2 X 10(6) CFU of E. coli O78:K80:H9. Turkeys injected with normal rabbit serum or saline solution before challenge served as controls. Fatalities (8 of 51 turkeys inoculated) occurred only in groups given saline solution or normal rabbit serum. The remaining turkeys were necropsied 96 h after challenge. Passive immunization with antiserum significantly (P less than 0.05) reduced the frequency of bacteremia at 96 h after challenge, the frequency of recovery of E. coli from air sacs, and the severity of gross lesions in inoculated birds as compared with birds given normal rabbit serum or saline solution.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference26 articles.
1. Effects of exogenous iron on Escherichia coli septicemia of turkeys;Bolin C. A.;Am. J. Vet. Res.,1986
2. Functional organization of the outer membrane of Escherichia coli: phage and colicin receptors as components of iron uptake systems;Braun V.;J. Supramol. Struct.,1976
3. The role of complement in host resistance to bacteria;Brown E. J.;Springer Semin. Immunopathol.,1983
4. Evidence that mucoid Pseudomonas aeruginosa in the cystic fibrosis Iung grows under iron-restricted conditions;Brown M. R. W.;FEMS Microbiol. Lett.,1984
5. Carbonetti N. H. and P. H. Williams. 1985. Detection of synthesis of the hydroxamate siderophore aerobactin by pathogenic isolates of Escherichia coli p. 419-424. In M. Sussman (ed.) The virulence of Escherichia coli. Academic Press Inc. New York.
Cited by
84 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献