Effect of Oral Antacid Administration on the Pharmacokinetics of Oral Fluconazole-Reference-Cited by-同舟云学术

Effect of Oral Antacid Administration on the Pharmacokinetics of Oral Fluconazole

Published:1990-10 Issue:10 Volume:34 Page:2032-2033
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Thorpe John E.¹,Baker Nigel¹,Bromet-Petit Maguy¹

Affiliation:

1. Departments of Clinical Research and Biometrics,2 Pfizer Central Research, Sandwich, Kent CT13 9NJ, United Kingdom, and Biosciences, 451000 Orleans, France3

Abstract

Absorption and elimination of fluconazole after oral administration of a 100-mg capsule were unaffected by concomitant administration of an antacid containing aluminum and magnesium hydroxides.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.34.10.2032

Reference13 articles.

1. Single-dose oral fluconazole in the treatment of vaginal candidosis;Brammer K. W.;Ann. N. Y. Acad. Sci.,1988

2. Brammer K. W. and M. H. Tarbit. 1987. A review of the pharmacokinetics of fluconazole (UK-49 858) in laboratory animals and man p. 141-149. In R. A. Fromtling (ed.) Recent trends in the discovery development and evaluation of antifungal agents. J. R. Prous Science Publishers S.A. Barcelona Spain.

3. Fluconazole in the management of oropharyngeal candidiasis in a predominantly HIV antibody-positive group of patients;Dupont B.;J. Med. Vet. Mycol.,1988

4. Graybill J. R. 1987. Fluconazole efficacy in animal models of mycotic diseases p. 113-124. In R. A. Fromtling (ed.) Recent trends in the discovery development and evaluation of antifungal agents. J. R. Prous Science Publishers S.A. Barcelona Spain.

5. The two-period cross-over trial;Hills M.;Br. J. Clin. Pharmacol.,1979

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